The show begins with music from offstage ("Prologue: Invisible"). In a graveyard, a Priest and Mourners attend the funeral of Emily Deetz, wife of Charles and mother of Lydia.

The crowd parts to reveal Beetlejuice ("The Whole "Being Dead" Thing"), who has a plan to bring himself back to life involving Adam and Barbara Maitland ("Ready, Set, Not Yet"). Their house has faulty electricity, and they are accidentally electrocuted. Beetlejuice produces The Handbook for the Recently Deceased and intercepts Adam and Barbara. Cheerleaders help Beetlejuice explain the Maitlands' situation ("The Whole "Being Dead" Thing - Part 2"): Movers have arrived, and unless Beetlejuice teaches Adam and Barbara to scare other people, they'll lose everything. The Maitlands agree ("The Whole "Being Dead" Thing - Part 3").

Charles and Delia, a self-proclaimed life coach, plan to turn the Maitlands' old house into a flagship model home. They are hiding their relationship from Lydia, Charles's daughter, who is still mourning. Charles reveals to Lydia that he's selling their old house and forcing everyone to move forward from her mother's death ("Let's Clean Up"). Lydia struggles with her grief and feels abandoned by her dad ("Dead Mom"). In the attic, Beetlejuice explains to Adam and Barbara that they must get the new people in the house to say "Beetlejuice" three times in a row.

Delia tries to connect with Lydia, giving her a yellow dress and explaining that Lydia needs a new perspective ("No Reason"). Delia exits, and Adam and Barbara arrive to scare Lydia… who isn't scared at all ("Ghosts"). The three become friends and hatch a plan to scare Charles.

As Charles is proposing marriage to Delia, Lydia, Adam, and Barbara try to scare them. However, Charles and Delia can't see the ghosts. Lydia, upset, goes up to the roof, where she encounters Beetlejuice ("Invisible - Reprise"). He tries to convince her that, instead of jumping off the roof, she should help him. He demonstrates his powers, including possession, on Adam and Barbara ("Say My Name"). Lydia pushes Beetlejuice off the roof, vowing to teach her dad a lesson with Adam and Barbara.

At dinner that evening, Maxie Dean and his model-wife Maxine arrive with a group of Lawyers. Lydia wears the yellow dress and invites Delia to make a toast. As Delia speaks, she is suddenly overcome by song, and the phenomenon spreads to the others ("Day-O - The Banana Boat Song"). Rather than being put off, Maxie Dean is thrilled.

Lydia's plan has failed, so she uses her last resort: Beetlejuice. The guests scatter in terror ("Showtime!").

Later, Sky and a few Girl Scouts approach the house ("Girl Scout"). Beetlejuice, Lydia, and his Clones scare them away ("That Beautiful Sound"). Lydia takes the Handbook from Beetlejuice, intent on finding her mom. He reveals to his clones that for him to become a living person, he needs to convince Lydia to marry him - but don't worry, it's just a "green card thing."

In the attic, Lydia, Adam, and Barbara follow instructions from the Handbook to go to the Netherworld, but Barbara stops them, claiming the book is dangerous. Lydia vows to do it herself.

Meanwhile, in the living room, Delia's guru, Otho, has arrived to perform an exorcism with a device called "The Soul Box." Beetlejuice tells Lydia that the box can be used to bring her mom back - but when Lydia tries, Barbara is put in danger. To save her, Lydia agrees to marry Beetlejuice. A door appears to send the Maitlands to the Netherworld, but Lydia leaps through instead, with Charles running after her.

In the Netherworld, Miss Argentina and a group of Recently Deceased try to convince Lydia and Charles to go back before JUNO finds them ("What I Know Now"). Lydia rushes deeper into the Netherworld, searching for her mom ("Home - Part 1"). Charles follows her, and the two finally have a conversation about their grief ("Home - Part 2"). They decide to go back home, where the house has been turned into a demonic game show. Lydia enters from the Netherworld wearing a red wedding dress and agrees to marry Beetlejuice, with Charles giving his blessing.

They bring Beetlejuice back to life only to immediately kill him, since, as one of the recently deceased, he'll be instructed to go directly to the Netherworld. Juno, who is Beetlejuice's mother, sends him to the Wasteland, but he returns on a giant sandworm just in time to save everyone else. Beetlejuice returns to the Netherworld, and Charles, Delia, Lydia, and the Maitlands decide to live in the house together ("Jump In The Line").